Pilar Sierra San Miguel, Servicio de Psiquiatría, Hospital Universitario y Politécnico La Fe, Departamento de Medicina. Universidad de Valencia, Valencia, España

Duloxetine is a dual action antidepressant included in the pharmacological class of serotonin–norepinephrine reuptake inhibitors. Its mechanism of action makes it a drug indicated for the treatment of clinical conditions than frequently coexist and share pathophysiological pathways such as major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, or chronic musculoskeletal pain. It is also indicated in other diseases that reduce quality of life such as chemotherapy induced peripheral neuropathy or stress urinary incontinence. All this with a favorable side effect profile. In this review, we will elucidate current evidences on the use of duloxetine in the treatment of these diseases and its use in special populations.

Keywords: Duloxetine. Major depressive disorder. Generalized anxiety disorder. Pain. Fibromyalgia.