Ane Mínguez-Olaondo, Servicio de Neurología, Hospital Universitario Donostia, San Sebastián; Athenea Neuroclinics, Policlínica Gipuzkoa, Grupo Quirónsalud Donostia, San Sebastián; Neuroscience Area, Biodonostia Health Institute, San Sebastián; Facultad de Medicina, Universidad de Deusto, Bilbao

Topiramate, which is classified as a sulphamate-substituted monosaccharide, is a drug whose data sheet shows its indication in epilepsy and migraine, although it is also used in other headaches such as cluster headache, SUNCT-SUNA, paroxysmal hemicrania, trigeminal nerve neuralgia, and headache secondary to idiopathic intracranial hypertension; neuropathic pain; movement disorders such as tremor, tics and Tourette’s syndrome; parasomnias; addictive disorders due to alcohol consumption or other substances; eating disorders such as bulimia or obesity, among others; post-traumatic stress disorder, bipolar disorder and obsessive- compulsive disorder. The aim of this paper is to review the knowledge and clinical uses of topiramate, both those included in its technical data sheet and those that are not, and the level of evidence for them.

Keywords: Topiramate. Epilepsy. Headache. Pain. Movement disorders. Off-label prescribing.